ABOUT THE LAB
Dr. Rowley’s research interests are centered on the complex interactions that occur between a virus and its host. The Rowley laboratory aims to better understand how viruses hijack host proteins and how antiviral host proteins thwart virus replication. The laboratory uses both mammalian cell culture and the model eukaryote Saccharomyces cerevisiae to understand how viral antagonism has shaped the evolution and function of host proteins. the Rowley lab is currently investigating the production of antifungal toxins encoded by virus-like elements in yeasts, SARS-CoV-2 cell entry, antiviral therapeutics, the mechanism of viral nuclear entry via the nuclear pore complex in primates, and how RNA metabolism has evolved as a potent antiviral defense mechanism within Saccharomyces yeasts.
"The vermin only tease and pinch
Their foes superior by an inch.
So, naturalists observe, a flea
Has smaller fleas that on him prey;
And these have smaller still to bite 'em,
And so proceed ad infinitum."
- Jonathan Swift